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Its activity is controlled by insulin-like growth factor binding proteins and the insulin-like growth factor-1 receptor (IGFR) ( 2.9 Follistatin In the liver, the ratio of glucagon to insulin regulates the secretion of cyclic Follistatin (Fst) ( FST gene can lead to early infertility and arrest of follicular development, similar to conditions observed in PCOS ( 2.10 FGF21 The liver is the main source of circulating fibroblast growth factor 21 (FGF21) ( 2.10.1 In glucose metabolism (116)
These are peripheral effects that depend on systemic circulating levels of the peptide
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